Fig. 3: The structures of NiV RdRp and PRNTase domains.
From: Cryo-EM structure of Nipah virus L-P polymerase complex
a The NiV RdRp contains a classical right-handed structure including fingers (blue), palm (red) and thumb (green) subdomains. b The catalytic motifs of RdRp including motifs A-F. c Structural comparison between NiV and NDV PRNTase domain. Both structures could be overlaid well, giving an RMSD value of 1.29 Å, the conserved motifs A’-E’ were labeled with different colors in the structure of NDV PRNTase. d The structure of NiV PRNTase domain, the motif B’ and motif D’ were not observed. e Conformation changes of the priming loop and supporting helix during the polymerase switching from initiation to elongation state. RMSD root-mean-square deviation, VSV Vesicular stomatitis virus, NDV Newcastle disease virus, EBOV Ebola virus.
