Fig. 3: Sociodemographic characteristics and Gaussian Graphic Model (GGM) of depression-anxiety inter-symptom network. | Nature Communications

Fig. 3: Sociodemographic characteristics and Gaussian Graphic Model (GGM) of depression-anxiety inter-symptom network.

From: Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety

Fig. 3

a The geospatial and socioeconomic statistics of this subclinical sample (GGBBP sample recruited from 2019 to 2022) demonstrate the geographic diversity. The scale indicated the number of included subjects after Log transformation. Icons in this panel were generated from the open-access web-based software (ICONFINDER, https://www.iconfinder.com/). The “male gender” icon by Anna Litviniuk, titled “Avatar, male, man icon”, used under Free for commercial use license, available at https://www.iconfinder.com/icons/403019/download/png/512. The “female gender” icon by Anna Litviniuk, titled “Avatar, user, woman icon”, used under Free for commercial use license, available at https://www.iconfinder.com/icons/403023/download/png/512. The “diversity” icon by Dumitriu Robert, titled “Guy, individual, man icon”, used CC-BY 3.0 license, available at https://www.iconfinder.com/icons/3289573/download/png/512. This icon is modified by changing colors and replicating in the figure, as permitted by this license. The “socioeconomic status” icon by Pongsakorn Tan, titled “Banking, business, cash icon”, used under Free for commercial use license, available at https://www.iconfinder.com/icons/4288564/download/png/512. The “family health” icon by Paomedia, titled “House icon”, used CC-BY 3.0 license, available at https://www.iconfinder.com/icons/299061/download/png/512. The “COVID-free” icon by Omeneko, titled “Corona, coronavirus, positive icon”, used CC-BY 3.0 license, available at https://www.iconfinder.com/icons/6217233/download/png/512. This geographic map, along with the compass label, was produced by the open-access software titled “EasyShu (3.61)” (https://www.yuque.com/easyshu/). b Mantel’s test plot was illustrated here (p < 0.001, one-sided Mantel’s test, uncorrected), and each point into the lower triangle indicated the mean values of corresponding items. c We illustrated the centrality of each symptom (item) from the network model in descending order, with the “D” for indicating “depressive symptom” and with the number of this label for indicating the item in this questionnaire (EI Expected Influence). d This showed density with Gaussian kernel function for each symptom by descending order, with each circuit (gray) for indicating the high integrative centrality. Source data are provided as a Source Data file.

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