Fig. 7: Specific enrichment of connectome-transcriptional markers. | Nature Communications

Fig. 7: Specific enrichment of connectome-transcriptional markers.

From: Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety

Fig. 7

a We showed the tissue-specific enrichment of this gene set (PLS1) by using both the Metascape124 tool and the Specific Expression Analysis (SEA) database. * indicated the q < 0.05 (two-sided cumulative hypergeometric distribution test, Benjamini–Hochberg FDR correction) that found in the Metascape database in the left panel, while the colors of circles indicated the q-values (Benjamini–Hochberg FDR) in the right panel. The size of the bullseye plots represents the proportion of genes in specific tissues at a given specificity index probability (pSI), which evaluates the level of gene enrichment specificity compared to others, using permutation tests. All the icons within this panel were generated by the web-based plotting platform FigDraw (https://www.figdraw.com/; Unique Copyright Code: YPTUR7d07d). Searching terms in this platform contained each tissue in this panel, including “body”, “brain”, “retina”, “bone”, “heart”, “muscle” and “kidney”, respectively. b Cell type-specific enrichment (left panel) and disease-specific enrichment (right panel) of this gene set (Two-sided cumulative hypergeometric distribution test, q < 0.05, Benjamini–Hochberg FDR correction) were shown. Full names of enriched diseases are detailed below: Down Syndrome (Down synd), Acute pancreatitis (Acute pan), Congenital chromosomal disease (CCD), Complete Trisomy 21 Syndrome (CT21 synd), Middle Cerebral Artery Occlusion (MCAO), Sleep-Apnea-Obstructive (OSA), Cardiomyopathy-Familial-Idiopathic (COP), Endothelial dysfunction (Endo anomaly), Transient Ischemic Attack (TAI), Subarachnoid Hemorrhage (SH), Fatty Liver Disease (FLD), and B-CELL MALIGNANCY-LOW-GRADE (MALIGNANCY). c Bullseye plots, along with q-values, have been illustrated to show the enrichment of the neurodevelopmental periods at different brain areas. d Bullseye plots to show the enrichment of SEA brain regions have been provided though no one reached the statistical significance. Source data are provided as a Source Data file.

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