Fig. 6: Dynamic study of the cortex vasculature by the PIN-PMN-PT-based TUT.

a Schematic diagram of a mouse with a cranial window. The Pentylenetetrazol (PTZ) solution was injected into the mouse to induce an epileptic seizure. The laser was focused on the cerebral cortex through the TUT and performed a fast 2D optical scan. b, c Changes of the cortex vasculature over time at normal and epileptic states, respectively. d Vessel diameters with respect to the time before and after the injection. The vessel diameter was calculated at the position marked by the green line in (b). e, f Detailed views of the regions marked by the blue and orange boxes in (d), where the dots highlighted the time points corresponding to the images in (b).