Fig. 2: Methylation characterization of NSCLC cohort. | Nature Communications

Fig. 2: Methylation characterization of NSCLC cohort.

From: Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer

Fig. 2

Distribution of DMRs in LUAD (a) and LUSC (b). c The comparison of methylation level between Rec (LUAD, n = 18 and LUSC, n = 5) and NonRec (LUAD, n = 10 and LUSC, n = 12) groups. P-values are obtained from unpaired two-sided Wilcoxon ranked-sum test. The boxes indicate the median value, interquartile range, with whiskers extending from the box boundaries to upper/lower quartile ± 1.5 interquartile range. d Venn diagrams depicting the hypomethylated and upregulated genes between Rec and NonRec groups in LUAD (top) and LUSC (bottom). Activity map integrating the association between methylation of TF binding site and expression of target genes in LUAD (e) and LUSC (f). g Correlation between methylation level of TEAD1 binding motif and PRAME expression. h Correlation of TEAD1 and PRAME expression. P-values are obtained from the two-sided t-test, and “R” represents the Pearson correlation coefficient. Source data are provided as a Source Data file.

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