Fig. 4: Replication kinetics of the pre-epidemic and epidemic ZIKV strains in human brain cells in vitro.
From: Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity
a Viral loads in neuroblastoma cells are shown as log10-transformed viral genome copies at different days post-infection (all strains n = 9, except for PF_2013 n = 6). b Infectious virus in neuroblastoma cells is depicted as log10-transformed TCID50 per ml of supernatant at different days post-infection (all strains n = 3). c Viral loads in human neural progenitor cells are shown as log10-transformed viral genome copies at different days post-infection (all strains n = 6, except for SUR_2016 n = 3). d Infectious virus in human neural progenitor cells is depicted as log10-transformed TCID50 per ml of supernatant at different days post-infection (all strains n = 6, except for SUR_2016 n = 3). Blue-colored dots/lines represent data of the two pre-epidemic ZIKV strains and purple-/red-colored dots/lines represent data of the five epidemic ZIKV strains in (a–d). Data are presented as mean values ± standard deviation. Statistical significance of differences was determined by two-way ANOVA followed by Šídák’s multiple comparisons test. Source data are provided as a Source Data file.
