Fig. 3: The cocktail of HB0038 and HB0039 forms a loop structure with CD73. | Nature Communications

Fig. 3: The cocktail of HB0038 and HB0039 forms a loop structure with CD73.

From: An antibody cocktail targeting two different CD73 epitopes enhances enzyme inhibition and tumor control

Fig. 3

A Visualization of the CD73 antigen (6TVG), Fab (1M71), and complete IgG (1IGY) docked within the electron density map derived from negative staining of the CD73-HB0039 IgG-HB0038 Fab complex. B Enzymatic assay results display the concentration-dependent inhibitory effects on soluble CD73 enzymatic activity by HB0038 IgG, HB0039 IgG, HB0038 Fab, and HB0039 Fab. Results represent two technical replicates from one of three independent experiments; data are presented as mean values ± SD.

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