Fig. 1: Schematic representation of the samples studied. | Nature Communications

Fig. 1: Schematic representation of the samples studied.

From: Liver cancer multiomics reveals diverse protein kinase A disruptions convergently produce fibrolamellar hepatocellular carcinoma

Fig. 1

This includes 1412 RNA-seq samples (FLC: 220, iCCA: 139, HBL: 148, HCC: 905. Some of these FLC samples were also studied through whole-genome and whole-exome sequencing (n = 39), targeted bisulfite methylation sequencing (n = 31), proteome sequencing (n = 15), and spatial single-cell transcriptomics (n = 6). We also developed FLC models, including 15 different PDX, 18 genetically engineered mice, 27 organoids, and primary human hepatocytes expressing the chimeras DNAJB1::PRKACA and ATP1B1∷PRKACA.

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