Fig. 9: Effects of anti-CD44 and anti-CD62L antibodies on neutrophil motility and platelet aggregates.

a Ob/Ob mice were infected intranasally with 10⁴ PFU MA-SARS-CoV-2-Venus, and on days 1, 2, and 3 after infection, anti-CD44 and anti-CD62L antibodies were administered intravenously. On day 4 after infection, a fluorochrome-conjugated anti-Ly-6G antibody was injected i.v. into the mice to track neutrophil movement. Tracking analyses were performed to obtain the trajectories of individual neutrophils (left panel, vascular structures are shown in white, and individual trajectories are coded in different colors). n = 5 biologically independent animals. b Assessment of neutrophil behaviors in (a) in terms of slow and rapid motion. c On day 4 after infection, a fluorochrome-conjugated anti-CD41 antibody was injected i.v. into the mice to visualize platelets. Histograms were plotted based on the size of the detected platelet (CD41-positive) signals (leftmost panel). n = 3 biologically independent animals. b, c Each dot represents data from an individual animal and the horizontal bars represent means ± SD. Source data are provided as a Source Data file.