Fig. 1: Study design and fallopian tube histology.

A Pre-menopausal fallopian tube (FT) fimbria (F; n = 10), ampulla (A; n = 10) and isthmus (I; n = 5) were characterized using scATAC-seq and scRNA-seq. To study the cellular and molecular changes driven by the menstrual cycle and by menopause in the normal human fallopian tube both datasets were integrated. B Representative hematoxylin and eosin (H&E) staining of normal pre-menopausal FT fimbria. Dashed lines and roman numerals indicate principal cell compartments defined by H&E in the FT. Black lines indicate stretches of ciliated (1) or secretory (2) epithelial cells, and (3) stromal cells. Different cell types identified in the FT by H&E are at higher magnification. Specific cell types are marked with circles or by an arrowhead and annotated by numbers. Created in BioRender. Weigert, M. (2024) BioRender.com/s53z837.