Fig. 2: Cellular composition of the normal pre-menopausal fallopian tube.
From: A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause
A Canonical cell types and subtypes found in the ampulla (n = 10) and fimbria (n = 10) of the normal pre-menopausal fallopian tube. The UMAP plot visualizes the 19 cell clusters identified using scRNA-seq. B Dot plot showing normalized gene expression levels of canonical marker genes associated with common cell types identified in the dataset (scRNA-seq). C The UMAP plot visualizing the 16 cell clusters identified in pre-menopausal ampulla (n = 5) and fimbria (n = 5) using scATAC-seq. Cell type labels were transferred from scRNA-seq data and match abbreviations described in (A). Cell types SE3, EN2 and B/P2 were not identified in this analysis. D Heatmap showing transcription factor (TF) activity enrichment by cell clusters based on scATAC-seq data. Abbreviations: SE1-3 = 3 subtypes of secretory epithelial cells; CE = ciliated epithelial cells; T/NK = T and natural killer cells; MP = macrophages; MN = monocytes; MA = mast cells; ST1-3 = 3 subtypes of stromal cells; SM = smooth muscle cells; LE = lymphatic endothelial cells; EN1-2 = 2 subtypes of endothelial cells; P/V1-2 = 2 subtypes of pericytes and vascular smooth muscle cells; B/P1-2 = 2 subtypes of B cells and plasma B cells.
