Fig. 2: Prime editing with mpegRNA strategy.
From: Mismatch prime editing gRNA increased efficiency and reduced indels
a The editing efficiency of prime editing mediated by mpegRNA at various mismatch positions across the protospacer in the UBE3A and EMX1 loci. b, c The efficiency and indel outcomes of PE2 and PE3 using pegRNA and mpegRNA with mismatches at positions three to eleven within the protospacer, where ST denotes the standard pegRNA without mismatches. For a single target locus, data are presented as the mean ± s.d. from n = 3 independent biological replicates. For the combined analysis of ten loci, data are presented as the mean ± s.d. from n = 30 independent biological replicates, with three replicates per locus. Only the group with the best performance underwent unpaired two-tailed Student’s t test (***p < 0.001, **p < 0.01, *p < 0.05, ns indicates no significant difference). Source data are provided as a Source Data file.
