Fig. 5: Structure and properties of mpegRNA predicted by AlphaFold 3.
From: Mismatch prime editing gRNA increased efficiency and reduced indels
a Overview of pegRNA distance measurements. b Distances between complementary base pairs of various mpegRNAs, with the protospacer base position plotted on the x-axis and the corresponding distance on the y-axis. c Average distances between complementary base pairs in the protospacer region of different mpegRNAs. d Micro-structural comparison of N6-mpegRNA and standard pegRNA (ST-pegRNA). e Structural analysis of three pegRNAs targeting the HEK3 locus.
