Fig. 2: Consensus subtyping yields intrinsic molecular subtypes associated with survival. | Nature Communications

Fig. 2: Consensus subtyping yields intrinsic molecular subtypes associated with survival.

From: The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer

Fig. 2

Overall survival (OS) according to consensus subtyping with respect to the IHC (immunohistochemistry) surrogate subtype according to IHC results, including Luminal A (a, n = 432), Luminal B (b, n = 313), HER2+ (c, n = 87), and TNBC (d, n = 181) stratified by nodal status (left and right panels depict node negative and positive, respectively). (e) Sankey diagram shows the IHC surrogate subtypes and the proportion (%) of samples reclassified by consensus subtyping. (f) Overall survival of consensus molecular subtypes (n = 1013). Survival curves were analyzed using the log-rank test to assess statistical significance. (g) Forest plots showing univariate and multivariate Cox proportional hazards models comparing prognostic utility of IHC surrogate vs Consensus molecular subtypes (n = 1013). Multivariate models included both tumor size (pT1 vs pT2-pT4) and node status (pN0 vs pN1-pN3). Hazard ratios show the overall survival estimates with 95% CIs, where the center of the interval represents the point estimate. P-values were obtained from the Wald test. Source data are provided as a Source Data file.

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