Table 1 Clinical characteristics of all and selected patients for this study included in HOVON-84 and PETAL trials

From: Integrating genetic subtypes with PET scan monitoring to predict outcome in diffuse large B-cell lymphoma

Characteristic

HOVON84-NGS

(n = 208)

HOVON84

(n = 574)

p-value

PETAL-NGS

(n = 204)

PETAL (n = 609)

p-value

p-value

(HOVON84-NGS vs. PETAL-NGS)

Age

  

7,97E-01

  

6,26E-02

0.005382

≤60

67 (32%)

192 (33%)

 

94 (46%)

292 (48%)

  

>60

141 (68%)

382 (67%)

 

110 (54%)

304 (50%)

  

Missing

0 (0%)

0 (0%)

 

0 (0%)

13 (2%)

  

Sex

  

8,08E-01

  

3,27E-01

0.07077

Female

102 (49%)

275 (48%)

 

81 (40%)

267 (44%)

  

Stage of disease

  

4,99E-02

  

9,19E-01

1,47E-10

I

0 (0%)

0 (0%)

 

40 (20%)

115 (19%)

  

II

38 (18%)

114 (20%)

 

41 (20%)

135 (22%)

  

III

48 (23%)

177 (31%)

 

42 (21%)

131 (21%)

  

IV

122 (59%)

283 (49%)

 

81 (40%)

227 (37%)

  

Missing

0 (0%)

0 (0%)

 

0 (0%)

1 (1%)

  

Serum LDH level

  

6,71E-01

  

7,64E-01

0.03018

≤ ULN

74 (36%)

195 (34%)

 

95 (47%)

273 (44%)

  

> ULN

134 (64%)

379 (66%)

 

109 (53%)

335 (55%)

  

Missing

0 (0%)

0 (0%)

 

0 (0%)

1 (1%)

  

ECOG ps

  

7,21E-01

  

2,23E-01

0.3309

0

112 (54%)

304 (53%)

 

106 (52%)

269 (44%)

  

1

67 (32%)

201 (35%)

 

77 (38%)

276 (45%)

  

2

27 (13%)

66 (11%)

 

19 (9%)

59 (10%)

  

Missing

2 (1%)

3 (1%)

 

2 (1%)

5 (1%)

  

# Extranodal sites

  

1

  

9,48E-01

0.07217

≤ 1

115 (55%)

318 (55%)

 

139 (68%)

410 (67%)

  

> 1

80 (39%)

221 (39%)

 

65 (32%)

198 (32%)

  

missing

13 (6%)

35 (6%)

 

0 (0%)

1 (1%)

  

IPI score

  

9,53E-01

  

7,19E-01

3,00E-06

0

0 (0%)

0 (0%)

 

25 (12%)

73 (12%)

  

1

14 (7%)

40 (7%)

 

52 (25%)

151 (25%)

  

2

55 (26%)

149 (26%)

 

45 (22%)

158 (26%)

  

3

70 (34%)

211 (37%)

 

48 (24%)

127 (22%)

  

4

44 (21%)

114 (20%)

 

28 (14%)

60 (11%)

  

5

10 (5%)

22 (4%)

 

6 (3%)

19 (3%)

  

Missing

15 (7%)

38 (6%)

 

0 (0%)

1 (1%)

  
  1. Statistical significance was determined using a two-sided Fisher’s exact test and shown as unadjusted p-values. P-values of significant comparisons (p < 0.05) are highlighted in bold. LDH Lactate dehydrogenase, ULN upper limit of normal, ECOG PS Eastern Cooperative Oncology Group performance status, IPI international prognostic index.
Back to article page