Table 1 Ion channel densities in a model CA1 pyramidal cell. Channel models were adapted from Ref. 49
From: Dendritic excitations govern back-propagation via a spike-rate accelerometer
Dendritic properties | ||||||
|---|---|---|---|---|---|---|
Channel Name | Proximal (mS/cm2) | Distal (mS/cm2) | d1/2 (μm) | z (μm) | ||
NaV (ḡNaV) | 50 | 47 | 300 | 100 | ||
A-type KV (ḡKA) | –200* | 300 | 0 | 150 | ||
Delayed rectifier KV (ḡKDR) | 40 | 40 | N/A | N/A | ||
NaV slow inactivation (smax) | 0% | 60% | 300 | 100 | ||
Axonal properties | ||||||
Channel properties | Parameters | Location | ||||
NaV (ḡNaV) | 30 S/cm2 | Nodes of Ranvier | ||||
NaV (ḡNaV) | 15 S/cm2 | Axon initial segment | ||||
NaV (ḡNaV) | 50 mS/cm2 | Axon (other segments) | ||||
A-type KV (ḡKA) | 9.6 mS/cm2 | Nodal and internodal compartments | ||||
A-type KV (ḡKA) | 48 mS/cm2 | Axon (AIS and hillock) | ||||
Membrane capacitance (Cm) | 0.04 μF/cm2 | Internodal compartments, myelinated | ||||
Constitutive properties | ||||||
Membrane capacitance (Cm) | 1.5 μF/cm2 | All compartments except axon | ||||
Specific membrane resistance (Rm) | 80,000 Ω·cm2 | Uniform, leak conductance | ||||
Specific axial resistance of the cytoplasm (ρ) | 200 Ω·cm | Uniform | ||||
