Fig. 9: Graphical summary of this study.
From: Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity
Under physiological conditions, cold exposure upregulates Nmt1 and Nmt2, which catalyzes the myristoylation of Eepd1, enabling its anchorage to the cell membrane. This modification of Eepd1 is essential for the activation of PKA and its downstream targets, HSL and p38 MAPK. High-fat diets or aging reduce Eepd1 levels, leading to impaired PKA activation and subsequent reductions in lipolysis and thermogenesis in adipose tissue, thereby accelerating obesity development. Administration of Retigabine dihydrochloride effectively restores Eepd1 levels, enhancing energy expenditure and counteracting obesity progression46.
