Fig. 7: Biodegradable and biocompatible characteristics of Bio-Restor. | Nature Communications

Fig. 7: Biodegradable and biocompatible characteristics of Bio-Restor.

From: A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries

Fig. 7

a Images of the Bio-Restor implanted at the injured sites of sciatic nerves in rodents at different stages of biodegradation over a time frame of 17 weeks. Inset: retrieved device isolated from regenerated nerve tissues. b Representative recorded signal traces and corresponding time-frequency spectrograms at different stages during the course of biodegradation. c Analysis of blood chemistry and blood counts of rats of the control (no device implantation) and Bio-Restor groups at 3 weeks postimplantation. n = 3 rats in each group, data are presented as mean ± s.d. ALT (Aminotransferase); TBIL (Total Bilirubin); BUN (Blood Urea Nitrogen); CR (Creatinine). Dash lines represent the normal range. d H&E-stained histological sections of heart, liver, spleen, lung, and kidney of the control and Bio-Restor groups at 3 weeks postimplantation. Experiments were repeated with n = 3 rats per condition.

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