Fig. 7: Inhibition of tumor recurrence by hydrogel vaccines.
From: Chiral polypeptide hydrogels regulating local immune microenvironment and anti-tumor immune response
A Schematic illustration of the postsurgical recurrence model. B Average tumor growth curves (n = 15 mice in each group). C Survival curves of postsurgical recurrence model (n = 15 mice in each group). D Individual tumor growth kinetics in each group (n = 15 mice in each group). CR was defined as complete disappearance of tumor on day 40. E Average tumor growth curves of re-challenged tumors inoculated on day 40 post-surgery (n = 8 mice in each group). F Survival curves of re-challenged model (n = 6 mice in D-Gel Vac+aPD-1 group or n = 8 mice in PBS group and L-Gel Vac+aPD-1 group). G Individual tumor growth kinetics in each group (n = 2 mice in Free Vac+aPD-1 group, n = 3 mice in Alum Vac+aPD-1 group, n = 6 mice in D-Gel Vac+aPD-1 group or n = 8 mice in PBS group and L-Gel Vac+aPD-1 group). CR was defined as complete disappearance of tumor on day 100. Data are presented as the mean ± SEM. Statistical significance was analyzed by one-way ANOVA using LSD posttest for five groups of data at the same time point and the P value marks the significance difference on Day 18 (B). Statistical significance was analyzed by two-tailed Student’s t-test (E) or a log-rank test (C, F). Source data are provided as a Source Data file.
