Fig. 7: Genome-wide gene expression profiles of C. glabrata wild-type strain and the ipi1R70H mutant in response to micafungin treatment.
C. glabrata cells were exposed to 1 µg/mL of micafungin in SC broth at 37 °C for 1 h. RNA-seq analysis was performed as described in the materials and methods. Venn diagrams show the number of differentially expressed genes in cells treated with micafungin relative to untreated controls (>2-fold change in expression, adjusted P -value of <0.05, DESeq2 analysis applying a two-sided test for each gene with multiple comparison adjustments using the Benjamini-Hochberg method). Representative Gene Ontology (GO) terms are shown (P < 0.05, ~5 terms in order from the term with the lowest P-value, one-sided binomial test with multiple comparison adjustments using the Bonferroni method). Note that no statistically significant term was found for genes upregulated only in the ipi1R70H mutant. Source data are provided in Supplementary Data 2.
