Fig. 5: Combination drive model.
From: Gene drive-based population suppression in the malaria vector Anopheles stephensi
Mosquitoes heterozygous for the drive allele and homozygous for the Cas9 allele were released into the population every week. A, B show the number of fertile females and the drive female frequency, respectively, over time at different release ratios. C Number of fertile females at various release ratios when the population is not eliminated. D Actual time needed to suppress the population when elimination is possible. Note that for the release ratio of 0.8, population elimination occurred in four out of 20 simulations, so this release level is shown in (C, D) to assess both situations.
