Fig. 1: Schematic illustration of functionally aligned nanoparticle-trapped nanoline arrays (FANTAs). | Nature Communications

Fig. 1: Schematic illustration of functionally aligned nanoparticle-trapped nanoline arrays (FANTAs).

From: Spatially controlled multicellular differentiation of stem cells using triple factor-releasing metal–organic framework-coated nanoline arrays

Fig. 1

a Differences between in vivo tissue development and in vitro cell differentiation for organ-mimicking models. b FANTAs consist of hierarchical nanoarrays including nanoline and nanohole nanopatterns with a spatially controlled distribution of nanocrystalline UiO-67s containing three osteogenic differentiation factors (ODFs), ascorbic acid, glycerol 2-phosphate, and dexamethasone (ODF⊂UiO-67), enabling the automatic, multicellular, spatially controlled differentiation (i.e., osteogenic and adipogenic differentiation) of mesenchymal stem cells (MSCs). This figure was partly generated by Servier Medical Art (Servier; https://smart.servier.com/), licensed under a Creative Commons Attribution 4.0 Unported License.

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