Fig. 1: Design of the Förster resonance energy transfer (FRET)-based tension sensor module and carbohydrate-binding module 1 (FTSM-CBM-1). | Nature Communications

Fig. 1: Design of the Förster resonance energy transfer (FRET)-based tension sensor module and carbohydrate-binding module 1 (FTSM-CBM-1).

From: Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues

Fig. 1

a A Förster resonance energy transfer (FRET) system with eCFP (Donor, D) and YPet (Acceptor, A) is selected as the tension sensor module (TSM). b Selection of TSM springs. Elastic spring selected from spider flagelliform silk. c An engineered flexible linker was used to link FTSMs and anchoring modules. d Carbohydrate-binding module 1 (CBM1, i.e. RR2 motif) was selected as the anchoring module. Insect cuticles as fiber-reinforced materials assembled with cuticular proteins and α-chitin. e Scheme of live stress distribution indicated by FTSM-CBM-1. f Expansion of the FTSM-CBM platform. The FTSM-CBM platform can be applied to detect structural stress in various substrates by changing the anchoring modules.

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