Fig. 1: FLAD1 is highly amplified and associated with tumor progression in TNBC. | Nature Communications

Fig. 1: FLAD1 is highly amplified and associated with tumor progression in TNBC.

From: Copy number amplification of FLAD1 promotes the progression of triple-negative breast cancer through lipid metabolism

Fig. 1

a Schematic diagram of the screening for the metabolic genes that were significantly amplified and highly expressed in TNBC. b Correlations between FLAD1 copy number and mRNA expression levels in the FUSCC TNBC and TCGA cohorts12,19. c FLAD1 mRNA expression between tumor tissues and adjacent normal tissues in the FUSCC and TCGA TNBC cohorts. d FLAD1 mRNA expression in the FUSCC TNBC and TCGA cohorts according to different T stages and histologic grades. e Kaplan-Meier survival analysis of FLAD1 mRNA expression in the FUSCC TNBC cohort and protein expression in the TNBC samples in the KMPlot database based on the optimal best cut-off. TNBC, triple-negative breast cancer. The center line represents the median, the box shows the interquartile range (IQR), and the whiskers extend to 1.5×IQR beyond the 25th and 75th percentiles. b–d P value was calculated by two-tailed Student’s t-test. e P value of the survival curve was calculated by log-rank test. Source data are provided as a Source Data file.

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