Fig. 8: SIMO reveals spatial regulation patterns in human myocardial infarction.
From: Spatial integration of multi-omics single-cell data with SIMO
a Spatial regulation modules of cardiomyocyte cells were identified using SIMO. b SIMO maps of the activity score of gene-motif pairs within modules of cardiomyocytes. c The activity scores of gene-motif pairs within module 1 and their correlation with the distance to the infarct area (left) and myeloid cells (right). Statistical analysis was performed using a two-sided linear regression model (ordinary least squares, OLS). d GSEA analysis results of module1-related genes. The Benjamini-Hochberg (BH) method was applied for multiple comparison adjustment. e SIMO maps of the activity score of gene-motif pairs within modules of fibroblasts. f GO analysis results of module2-related cell genes, including Biological Process (BP) and Molecular Function (MF) categories. The BH method was applied for multiple comparison adjustment.
