Fig. 3: A unique role for macrophages in NSCLC.
From: Spatially mapping the tumour immune microenvironments of non-small cell lung cancer
A Heatmap of cell types distributed across 30 neighbourhoods discovered in LUAD (n = 102) and LUSC (n = 102) (10 nearest neighbours, 30 neighbourhoods). B Distribution of cell types in CN15, CN23, and CN26 discovered in LUAD and LUSC (10 nearest neighbours, 30 neighbourhoods). Legend for other cell types can be seen in J. C Kaplan–Meier analysis of overall survival in CN15 high (z-score ≥0, n = 19) and CN15 low (z-score <0, n = 32) LUAD patients. Log-rank Mantel–Cox test. D Kaplan–Meier analysis of overall survival in CN23 high (z-score ≥0, n = 22) and CN23 low (z-score <0, n = 29) LUAD patients. Log-rank Mantel–Cox test. E Kaplan–Meier analysis of overall survival in CN26 high (z-score ≥0, n = 11) and CN26 low (z-score <0, n = 40) LUAD patients. Log-rank Mantel–Cox test. F Heatmap of cell types distributed across 30 neighbourhoods discovered in LUAD (n = 102) and LUSC (n = 102) (3 nearest neighbours, 30 neighbourhoods). G Distribution of CD163+ macrophages across cellular neighbourhoods discovered in LUAD and LUSC (3 nearest neighbours, 30 neighbourhoods). Neighbourhoods with no CD163+ macrophages excluded from graph. H Kaplan–Meier analysis of overall survival in CN26 high (z-score ≥0, n = 16) and CN26 low (z-score <0, n = 35) LUSC patients. Log-rank Mantel–Cox test. I Kaplan–Meier analysis of disease-free survival in CN26 high (z-score ≥0, n = 9) and CN26 low (z-score <0, n = 42) LUAD patients. Log-rank Mantel–Cox test. J Cellular composition of CN26 and CN19 discovered in LUAD and LUSC (3 nearest neighbours, 30 neighbourhoods). LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, Cl Monocyte classical monocyte, Non-Cl Monocyte non-classical monocyte, Int Monocyte intermediate monocyte, NK cell Natural Killer cell, Treg regulatory T cell.
