Fig. 1: Identification of ginger secondary metabolites as human nuclear receptor ligands. | Nature Communications

Fig. 1: Identification of ginger secondary metabolites as human nuclear receptor ligands.

From: An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice

Fig. 1

a, b Relative abundance of NR expression in GTEx colon-sigmoid (n = 373) and colon-transverse (n = 406) specimens obtained from the GTEx Portal. The center line of the boxplot indicates the median value. Whiskers are drawn to 10% and 90% values with points below and above indicated as individual points. c–f Volcano plots showing the distribution of mass features differentially enriched by PXR, CAR, RXRβ, and RXRγ from ginger in comparison to vehicle (DMSO). p-values were determined by a two-tailed unpaired Student’s t-test. Dashed lines represent significance cut-offs (p-value ≤ 0.05, fold change ≥ 1000). Masses of enriched metabolites are highlighted. g Mass features identified in (c–f) are selectively enriched by the corresponding receptors. Pulldowns were performed in triplicate in at least three independent experiments, and data are expressed as mean ± SD. h Structure of FDN. E labels indicate double bond geometry. TPM transcript per million, FDN furanodienone. Source data are provided in the Source Data file.

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