Fig. 5: FDN beneficial activities are PXR-dependent. | Nature Communications

Fig. 5: FDN beneficial activities are PXR-dependent.

From: An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice

Fig. 5

a–d Colitis induced using DSS in wild-type C57BL/6 (6–8-week age old, n = 6 mice/group), and Nr1i2−/− (6–8-week age old, n = 6 mice/group) mice. Mice were pre-treated for 3 days by intragastric administration with either vehicle, FDN (10 mg/kg), or PCN (10 mg/kg) and then for another 7 days during DSS treatment. a, c Percentage body weight loss. b, d Disease activity index. e, f Representative colon images. g Colon lengths. h Microphotographs of H&E stained sections. Scale bar indicates 100 μm. n = 3 mice per group, a representative example is shown. i–k colonic IL-6, IL-1β and TNF-α levels (n = 6 mice). a–d Data were analyzed by one-way ANOVA and are expressed as mean ± SEM. g, i–k Data were analyzed by two-way ANOVA with multiple comparisons and are expressed as mean ± SD. p-values were determined by comparison to the DSS group. FDN furanodienone, PCN pregnenolone-16a carbonitrile, DSS dextran sodium sulfate. Source data are provided in the Source Data file.

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