Fig. 6: Analysis of the differentially expressed genes between the treatment-sensitive and resistant groups. | Nature Communications

Fig. 6: Analysis of the differentially expressed genes between the treatment-sensitive and resistant groups.

From: Regorafenib plus sintilimab as a salvage treatment for microsatellite stable metastatic colorectal cancer: a single-arm, open-label, phase II clinical trial

Fig. 6

a A total of 4135 differentially expressed genes were identified in this study, and the gene heatmap shows the relative expression levels of the genes in the treatment-sensitive and treatment-resistant groups. b Volcano plot showing that a total of 2497 genes were upregulated and 1638 genes were downregulated in the treatment-sensitive group compared with the treatment-resistant group. c, d KEGG analysis showing the gene enrichment related to multiple metabolic pathways, including lipid metabolism, carbohydrate metabolism, amino acid metabolism. e GSEA analysis showing the gene enrichment related to multiple metabolism-related and immune-related pathways. Source data are provided as a Source Data file.

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