Fig. 1: High-throughput screening identified siRNAs that induce HSC myofibroblast inactivation. | Nature Communications

Fig. 1: High-throughput screening identified siRNAs that induce HSC myofibroblast inactivation.

From: Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

Fig. 1

a Overview of the siRNA screen. b Results of the primary siRNA screen. Each dot represents the integrated score and toxicity value of three replicates of an experimental or control well. Data from all wells are shown. c The score and toxicity values for all experimental wells from the primary screen. d Summary of the validation screen results. e Summary of the siRNA knockdown efficiency in the cherrypick screen. f Grouping the final 71 hits by priority. g Expression of the 11 priority 1 genes in HSCs from the livers of CCl4-treated and control mice based on single-cell RNA sequencing results16. Circle size represents the fraction of cells expressing a gene, and color indicates mean expression level. Source data are provided as Supplementary Data 1–6 and a Source Data file.

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