Fig. 3: Gene transcription programs associated with long vs. short OS. | Nature Communications

Fig. 3: Gene transcription programs associated with long vs. short OS.

From: Improved overall survival in an anti-PD-L1 treated cohort of newly diagnosed glioblastoma patients is associated with distinct immune, mutation, and gut microbiome features: a single arm prospective phase I/II trial

Fig. 3

A Patients were separated into long vs. short OS groups based on a median threshold (red=deceased, green=alive). Patient age, sex, and tumor MGMT methylation status are as noted. Transcriptomic gene set enrichment was performed, the heatmap represents the relative expression levels of genes for each patient’s GBM tumor sample. Sankey plot connects specific genes with corresponding enriched Hallmark genesets. B Representative differentially expressed genes between GBM tumors from patients with short (n = 17) vs. long (n = 22) OS. The “box” shows the interquartile range (IQR) between the 25th and 75th percentiles, the “center line” marks the median, the “whiskers” extend to 1.5 times the IQR, and points beyond are outliers, with “minima” and “maxima” as the absolute lowest and highest values. C Differential cytolytic score between GBM tumors from patients with short (n = 17) vs. long (n = 22) OS. Source data are provided as a Source Data file.

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