Fig. 4: Pro-inflammatory changes in innate immune status after cytoreductive surgery. | Nature Communications

Fig. 4: Pro-inflammatory changes in innate immune status after cytoreductive surgery.

From: Immune checkpoint inhibitors plus debulking surgery for patients with metastatic renal cell carcinoma: clinical outcomes and immunological correlates of a prospective pilot trial

Fig. 4

a UMAP projection of myeloid cell subclusters in peripheral blood. b Dot plot indicating the. average expression of indicated genes as well as the percentage of cells expressing the gene to define myeloid subclusters. c–e Box plots of frequency of cDCs (c), HLA-DRhi monocytes (d), and KDM6B+HIF1A+ monocytes (e), from patients who underwent surgery (n = 10) or biopsy (n = 9) comparing post-surgery or post-biopsy samples to baseline (BL). Box plots represent the median, interquartile range and the whiskers represent 1.5 x the upper and lower interquartile range values. P values indicated were analyzed using two-sided Wilcoxon signed-rank test. f, g Identity of differentially expressed genes (DEGs) in cDCs (f) and KDM6B+HIF1A+ monocytes (g) from PBMCs. P values indicated were analyzed using two-sided Wilcoxon rank-sum test and Bonferroni adjustment was performed for multiple comparisons.

Back to article page