Fig. 1: The structure of RyR1(S0/5 mM[Ca2+]) and binding sites of S0.
From: Structural insights into transmembrane helix S0 facilitated RyR1 channel gating by Ca2+/ATP
a The cryo-EM density map of S0/5 mM[Ca2+] shows an extra density, indicating an extra TM helix S0 with a small loop in lumen (dark green). Three RyR1 subunits (I, II, and III) are shown in the cutting section to allow a clear visualization of S0. The model of S0/5 mM[Ca2+] in S0 and luminal domain (red box in (a)) are illustrated in side-view (b), cytoplasmic view (c), and luminal view (d). e, f are enlarged regions from c (circle) and d (rectangle), respectively. I, II, III, and IV represent four subunits in the RyR1 tetramer. * indicates the mutagenesis in patients with a family history of congenital myopathy (CCD).
