Fig. 5: ATVTfR and ATVCD98hc exhibit distinctly different localization to BEC subtypes compared to control IgG across the arteriovenous axis. | Nature Communications

Fig. 5: ATVTfR and ATVCD98hc exhibit distinctly different localization to BEC subtypes compared to control IgG across the arteriovenous axis.

From: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

Fig. 5

a–c Bar graph represent mean percent of total huIgG distribution across arterial, capillary, and venous endothelial cells captured per treatment group across fluorescence intensity bins. Points represent individual mice. Numbers displayed represent the total number of BEC subtypes captured. Control IgG (n = 2/group); ATVTfR and ATVCD98hc (n = 4/group).

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