Fig. 2: Detailed interactions between NPs and VP24s within the Ebola virus nucleocapsid-like structure.
From: Structural basis for Ebola virus nucleocapsid assembly and function regulated by VP24
a Atomic model of the NCLS showing the helical repeating unit containing two NPs (NP-1 in pink and NP-2 in beige) and two VP24 molecules (VP24-1 in lime green and VP24-2 in violet). b Close-up view of the interface between the 169–173 loop of VP24-1 and the α18 helix of NP-1, with the mesh representing the cryo-EM map. c Electrostatic surface potential maps of the NCLS from two orientations, 180° apart. The maps show the distribution of charges around NP-1 and NP-2, with VP24-1 and VP24-2, respectively. Electrostatic surface potential was calculated using the Delphi web-server57. Scale from −5 (red) to +5 kcal mol−1 e−1 (blue). d Close-up view of the NP-1 and VP24-1 interface, detailing electrostatic contacts. Residues possibly involved in interactions labeled and presented in stick representation. e Close-up view of the NP-2 and VP24-2 interface.
