Fig. 3: Sankey plots illustrating associations between phthalate exposure, metabolite perturbations, and NICU Neonatal Neurobehavioral Scale (NNNS) outcomes at two visits.
From: Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment
Sankey plots in a are from visit 1 (n = 81), and b are from visit 2 (n = 71). The first node is the phthalate exposures, leading to the associated metabolites in the second node, and ending at the NNNS outcomes, attention and arousal, in the last node. The yellow/blue colors on the left-hand side indicate different phthalate metabolites. The red colors on the right-hand side differentiate attention (dark red) and arousal (light red) or both (orange) outcomes. Only significant, annotated findings are displayed in this figure; for details on the significance level and beta values, please see Table 4. Source data are provided as a Source Data file. MEP Monoethyl phthalate, MBP Mono-n-butyl phthalate, MiBP Monoisobutyl phthalate, MBzP Monobenzyl phthalate, MEHP Mono-2-ethylhexyl phthalate, MEOHP Mono-2-ethyl-5-oxohexyl phthalate, MEHHP Mono-2-ethyl-5-hydroxyhexyl phthalate, MECPP Mono-2-ethly-5-carboxypentyl phthalate, \(\Sigma\)DEHP Sum of Di-2-ethylhexyl phthalate metabolites.
