Fig. 3: Survival Analysis of Carriers vs Non-Carriers for Burden of Variants in Significant Genes. | Nature Communications

Fig. 3: Survival Analysis of Carriers vs Non-Carriers for Burden of Variants in Significant Genes.

From: Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes

Fig. 3

Survival curves comparing carriers and non-carriers of variants on genes with a significant burden of loss-of-function (A) and AlphaMissense pathogenic (B) variants. For each gene, the survival curve includes Cox regression hazard ratio (HR), p value, the number of carriers, and their proportion within the total sample. A gene-wide significance threshold of \(p\) = 7.4\(\times {10}^{-7}\) was applied.

Back to article page