Table 1 Significant genes for rare variants association with burden and SKAT-O tests (\({{p}}\)<7.4\({\times {{10}}}^{-{{7}}}\))
From: Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes
Variant class | Chr | Gene | # of variants | # of carriers | Burden p value | SKAT-O p value |
|---|---|---|---|---|---|---|
LoF | 4 | TET2 | 243 | 563 | 2.6 \(\times {10}^{-34}\) | 1.2 \(\times {10}^{-60}\) |
11 | ATM | 247 | 1170 | 6.4 \(\times {10}^{-10}\) | 5.0 \(\times {10}^{-11}\) | |
13 | BRCA2 | 245 | 1271 | 1.2 \(\times {10}^{-33}\) | 3.5 \(\times {10}^{-41}\) | |
15 | CKMT1B | 15 | 40 | 4.3 \(\times {10}^{-7}\) | 1.5 \(\times {10}^{-6}\) | |
17 | BRCA1 | 120 | 456 | 5.6 \(\times {10}^{-12}\) | 1.6 \(\times {10}^{-11}\) | |
20 | ASXL1 | 72 | 533 | 1.3 \(\times {10}^{-51}\) | 6.8 \(\times {10}^{-54}\) | |
AlphaMissense | 1 | C1orf52 | 23 | 175 | 2.5 \(\times {10}^{-5}\) | 7.2 \(\times {10}^{-8}\) |
2 | DNMT3A | 167 | 1229 | 6.9 \(\times {10}^{-12}\) | 6.7 \(\times {10}^{-13}\) | |
2 | SF3B1 | 64 | 195 | 1.9 \(\times {10}^{-13}\) | 2.6 \(\times {10}^{-18}\) | |
4 | TET2 | 159 | 826 | 9.2 \(\times {10}^{-8}\) | 1.4 \(\times {10}^{-7}\) | |
10 | PTEN | 50 | 71 | 1.6 \(\times {10}^{-8}\) | 5.9 \(\times {10}^{-11}\) | |
13 | SOX21 | 52 | 463 | 2.2 \(\times {10}^{-8}\) | 3.2 \(\times {10}^{-8}\) | |
15 | IDH2 | 89 | 349 | 1.4\(\times {10}^{-4}\) | 5.4 \(\times {10}^{-42}\) | |
17 | TP53 | 35 | 90 | 8.6 \(\times {10}^{-17}\) | 6.2 \(\times {10}^{-17}\) | |
17 | SRSF2 | 14 | 141 | 1.8 \(\times {10}^{-94}\) | 1.9 \(\times {10}^{-114}\) | |
X | RLIM | 25 | 51 | 6.0 \(\times {10}^{-7}\) | 2.9 \(\times {10}^{-9}\) |
