Fig. 3: Activation of endothelial Myc leads to upregulation of P-selectin. | Nature Communications

Fig. 3: Activation of endothelial Myc leads to upregulation of P-selectin.

From: Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells

Fig. 3

a qPCR analysis of indicated genes in BDL livers (n = 5). b GSEA of the indicated gene sets. c DEGs in the indicated gene set. d Expression levels of indicated genes in RNA-seq data (n = 4). The box plot shows the data distribution, with the minimum (lower whisker), lower quartile (bottom of the box), median (center line within the box), upper quartile (top of the box), and maximum (upper whisker) indicated. e qPCR analysis of indicated genes in BDL livers (n = 5). f UMAP showing the expression of indicated genes. Representative IF images (g) and quantitative analysis (h) of IF for CD31+P-selectin+ ECs in sham- and BDL-treated livers (n = 6). Data are presented as the mean ± SEM. P values are indicated as follows: * <0.05; ** <0.01; * **** <0.0001, ns = no significance. P values were obtained using the unpaired two-tailed Student’s t-test. Source data are provided as a Source Data file.

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