Fig. 3: Molecular characteristics of Kp isolates.

A, B) Cumulative prevalence of K-loci ordered by mean prevalence across specimen type and virulence factors (VFs). Lines in Fig. 3A are colored by specimen type as per panel A of Fig. 1. Lines in Fig. 3B are colored by VFs. 5VF: isolates harboring all five key virulence factors, including iucA, iroB, peg-344, rmpA, and rmpA2. 1-4VF: isolates harboring any combination of fewer than five key virulence factors. 0VF: isolates harboring none of the five key virulence factors. C, D Cumulative prevalence of predicted O-types ordered by mean prevalence across specimen type and VFs. E Distribution of the number of acquired antimicrobial resistance (AMR) genes between the hvKp-p and cKp-p isolates, stratified by specimen type. F Distribution of the number of AMR genes across four groups: cKp-p cohort without ICU admission (n = 732), cKp-p cohort with ICU admission (n = 320), hvKp-p cohort without ICU admission (n = 102) and hvKp-p cohort with ICU admission (n = 25). Bars are colored by ICU admission status (blue = not admitted, red = admitted). The center line represents the median, the box bounds the 25th and 75th percentiles, and the whiskers extend up to 1.5 × IQR. A two-tailed Kruskal-Wallis test was performed, followed by Dunn’s post-test with Bonferroni correction for multiple comparisons. P-values from left to right: < 0.001, < 0.001, < 0.001. *: P-value between 0.01 and 0.05, **: P-value between 0.001 and 0.01, ***: P-value < 0.001. G Frequency of genomes with different VFs, shown by ESBL, CRKP, and KPC gene status. Bars are colored by specimen type as shown in Panel A of Fig. 1. Source data are provided as a Source Data file.