Fig. 9: ZTP riboswitch folding states.

Diagram of on-pathway and off-pathway ZTP riboswitch folding states. Secondary structures are adapted from ref. ⁴⁰ and were updated using structure probing data from ref. ³⁸. Purple nucleotides indicate structures within the apo ZTP aptamer that are stabilized by ZMP binding. Green nucleotides indicate the stabilization of these structures and other nucleotides that exhibit ZMP-dependent changes in benzoyl cyanide and/or dimethyl sulfate reactivity in TECprobe-VL⁴⁰ experiments.