Fig. 3: Elevated mutational load in co-diversified LGM strains compared to WGM relatives.
From: Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice
a Density plot shows significant genome-wide elevation of dN/dS (a hallmark of genetic drift) in co-diversifying GM strains in laboratory house mice relative to wild house mice. dN/dS values for all genes from all co-diversifying clades ancestral to murids and containing MAGs from both laboratory and wild mice are shown. b–e Density plots show the distribution of per-gene dN/dS values for four co-diversifying clades displaying the most significant genome-wide elevation of dN/dS in laboratory house mice relative to wild house mice. In a–e, significance of paired, two-sided t-tests for differences in mean is denoted by asterisks; **p-value < 0.01; ***p-value < 0.001; **** p-value < 0.0001 (Benjamini-Hochberg corrected p-values are provided in Supplementary Data 10). Top asterisks denote significance of tests considering all genes, and bottom asterisks denote significance of tests considering only genes displaying dN/dS < 1 (log dN/dS < 0) in both laboratory and wild mice. Source data are provided as a Source Data file.
