Fig. 3: Sex-specific associations between proteins and myocardial infarction (MI) using the visceral adiposity cluster polygenic score. | Nature Communications

Fig. 3: Sex-specific associations between proteins and myocardial infarction (MI) using the visceral adiposity cluster polygenic score.

From: Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes

Fig. 3

Panel A shows the increased risk of MI in male individuals without type 2 diabetes (T2D) (N = 155,271; 8038 cases) in the visceral adiposity cluster. Data points represent the effect size (odds ratio) for the cluster’s association with MI. Error bars indicate 95% confidence intervals (CIs) calculated using logistic regression models. All statistical tests were two-sided. The vertical line at 1 represents the null effect (no association). Panel B shows 39 proteins that displayed sex interaction; higher levels in males compared with females. The values in the heatmap are the beta estimates from regression analysis of the visceral adiposity cluster polygenic score with Myocardial Infarction (MI) in the UK Biobank. Panel C displays the proteins that showed mediation effects with P < 10−280. p values were adjusted for multiple comparisons of 0.05/39 proteins tested (p = 0.0012). Source data are provided as a Source Data file.

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