Fig. 2: Reaction discovery and optimization.
From: Asymmetric reductive arylation and alkenylation to access S-chirogenic sulfinamides
a Analysis of reaction parameters in the reaction of sulfinylamine I and iodoarene 1a. b Evaluation of diverse sulfinylamines. aReaction conditions: [Ni] (15 mol%), L* (18 mol%), 1a (3.0 equiv., 0.3 mmol), sulfinylamine I (1.0 equiv., 0.1 mmol), Zn dust (3.0 equiv., 0.3 mmol) in CH3CN (superdry, water ≤ 10 ppm) at 40 oC for 5 days under N2 atmosphere. The yields mentioned are isolated yields. E.r. values were determined via chiral HPLC bReact for 3 days with 1a (1.0 equiv., 0.1 mmol) and IV (3.0 equiv., 0.3 mmol).
