Fig. 6: The drug sensitivity profiles of the PAAD organoids.

a Assay description for individual organoids. Each column represents a PAAD organoid, and blue indicates that sequencing experiment or drug sensitivity data are available whereas gray indicates the absence of data. b The treatment response of 46 pancreatic adenocarcinoma (PAAD) organoids to 63 different drugs. The colors from red to blue represent Z-scores based on AUC (Methods). A low z-score or blue indicates high sensitivity and red indicates low sensitivity. The germline mutation and somatic mutation information of the PAAD organoid are shown in the top panel. c The treatment response of 15 PAAD organoids to 15 CFTR-related drugs, including CFTR potentiators, inhibitors, and correctors. d Dose-response curves generated from 15 PAAD organoids treated with CFTR correctors. Curve for CFTR p.R297Q PODs is labeled in blue. Curves for CFTR p.E681V PODs are labeled in yellow. Curve for CFTR p.H949P PODs is labeled in purple. PODs with wild type CFTR are labeled gray. e Comparing sensitivity to CFTR correctors between organoids with wild type CFTR (n = 11) and with CFTR mutations (n = 4). Statistical significance was computed by two-sided Wilcoxon test. Box indicates the 25th to 75th percentile values, the line indicates the median, with the lower whiskers representing the minimum 25% of data values and the whiskers above the box representing the 25% maximum values. Source data are available as a Source Data file.