Fig. 3: Adoptive transfer of c-kit+ cDC1 protects against the development of MASH in mice. | Nature Communications

Fig. 3: Adoptive transfer of c-kit+ cDC1 protects against the development of MASH in mice.

From: Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death and liver inflammation in metabolic dysfunction-associated steatohepatitis

Fig. 3

a A schematic of the adoptive transfer experiment. b Liver cytokine content. n = 8/group. c Quantity of liver immune cells. n = 8/group. d Liver coefficient. n = 8/group. e GTT with corresponding AUC. n = 8/group. f ITT with corresponding AUC. n = 8/group. g Liver TG content. n = 8/group. h Serum ALT and AST activity. n = 8/group. i H&E, Sirius red staining, and NAS. Magnification ×40, scale bar = 100 µm. n = 8/group. j Liver hydroxyproline content. n = 8/group. k Liver ACTA2 mRNA level. n = 8/group. Data were represented as mean ± SEM and analyzed using one-way ANOVA with Tukey’s post hoc test (b–k). Significance levels were reported as *P < 0.05, **P < 0.01. AUC area under curve, TG triglyceride, GTT glucose tolerance test, ITT insulin tolerance test, H&E hematoxylin and eosin, NAS NAFLD activity score, ALT alanine aminotransferase, AST aspartate aminotransferase. Source data were provided as a Source Data file.

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