Fig. 7: Gut-derived H2S reduces hepatic c-kit+ cDC1 and promotes the development of MASH in mice. | Nature Communications

Fig. 7: Gut-derived H2S reduces hepatic c-kit+ cDC1 and promotes the development of MASH in mice.

From: Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death and liver inflammation in metabolic dysfunction-associated steatohepatitis

Fig. 7

a Liver H2S concentration in NCD and WD mice. n = 8/group. b Liver H2S concentration in mice after microbiota transfer. n = 8/group. c Schematic of the H2S delivery. d Quantity of liver immune cells. n = 8/group. e Liver cytokines content. n = 8/group. f Quantity of hepatic c-kit+ cDC1. n = 8/group. g AUC of GTT and ITT analysis. n = 8/group. h Liver TG content. n = 8/group. i Serum ALT and AST activity. n = 8/group. j Liver coefficient. n = 8/group. k H&E staining and NAS. n = 8/group. l Liver hydroxyproline level. n = 8/group. m Liver ACTA2 mRNA level. n = 8/group. Data were represented as mean  ±  SEM. P values calculated by a two-tailed unpaired Student’s t-test (d–m), one-way ANOVA with Tukey’s post hoc test (b) or two-way ANOVA with Tukey’s post hoc test (a). Significance levels were reported as *P < 0.05, **P < 0.01. a–d the same letters indicate no significant differences (P > 0.05), different letters mean a significant difference (P < 0.05). FMT fecal microbiota transplantation, AUC area under curve, GTT glucose tolerance test, ITT insulin tolerance test, H&E hematoxylin and eosin, NAS NAFLD activity score, TG triglyceride, ALT alanine aminotransferase, AST aspartate aminotransferase. Source data were provided as a Source Data file.

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