Fig. 1: Manhattan plots of EAS and cross-ancestry meta-GWASs for Aβ deposition. | Nature Communications

Fig. 1: Manhattan plots of EAS and cross-ancestry meta-GWASs for Aβ deposition.

From: Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

Fig. 1

a Manhattan plot of the GWAS meta-analysis for Aβ deposition in EAS (stage 1, n = 3855). b Manhattan plot of the cross-ancestry GWAS meta-analysis for Aβ deposition in EAS and EUR populations (n = 15,701). p values for GWASs were calculated using a fixed-effect inverse variance-weighted meta-analysis. The x-axis represents chromosomal position, and the y-axis represents the −log10(p value) for the association of variants with Aβ deposition. Reported p values are two-sided and not corrected for multiple testing. The light green dots represent the genome-wide significant lead variants. The red text highlights previously unreported loci along with their mapped genes, while the black text indicates previously reported loci. The pink and blue horizontal dashed lines indicate the genome-wide significance level (p value = 5.00 × 10−8) and the genome-wide suggestive level (p value = 1.00 × 10−5), respectively. EAS East Asian, EUR European, GWAS genome-wide association study.

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