Fig. 2: Regional plots for SORL1 signals associated with Aβ deposition. | Nature Communications

Fig. 2: Regional plots for SORL1 signals associated with Aβ deposition.

From: Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

Fig. 2

a Regional plot for SORL1 signals from the East Asian GWAS. b Regional plot for SORL1 signals from the European GWAS. c Regional plot for SORL1 signals from the cross-ancestry meta-GWAS. p values for GWASs were calculated using a fixed-effect inverse variance-weighted meta-analysis. Each dot is colored by r2 of linkage disequilibrium with the purple-colored lead SNPs indicated with texts. Reported p values are two-sided and not corrected for multiple testing. The x-axis represents chromosomal position, and the y-axis represents the −log10(p value) for the association of variants with Aβ deposition. EAS East Asian, EUR European, GWAS genome-wide association study, SE standard error, MAF minor allele frequency, gnomAD Genome Aggregation Database.

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