Table 2 Pathway enrichment analysis of candidate genes identified in cross-ancestry meta-analysis for Aβ deposition

From: Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

GO term (biological process 2023)

Odds ratio

Bonferroni-corrected

p value

Regulation of Amyloid-Beta Formation (GO:1902003)

201.5

2.83E−09

Negative Regulation of Amyloid Precursor Protein Catabolic Process (GO:1902992)

333.8

1.93E−08

Negative Regulation of Amyloid-Beta Formation (GO:1902430)

277.2

3.42E−06

Regulation of Aspartic-Type Endopeptidase Activity Involved in Amyloid Precursor Protein Catabolic Process (GO:1902959)

479.2

8.48E−05

Regulation of Amyloid Precursor Protein Catabolic Process (GO:1902991)

299.5

2.49E−04

Negative Regulation of Amide Metabolic Process (GO:0034249)

37.2

5.10E−03

Cholesterol Transport (GO:0030301)

49.8

3.03E−02

High-Density Lipoprotein Particle Assembly (GO:0034380)

219.4

4.19E−02

Regulation of Tau-Protein Kinase Activity (GO:1902947)

219.4

4.19E−02

Regulation of Neuron Death (GO:1901214)

43.5

4.46E−02

  1. Pathway enrichment analysis of candidate genes was performed using the gene ontology (biological process 2023) database. The analysis was based on the Fisher’s exact test. Reported p values are two-sided and were corrected for multiple testing using the Bonferroni correction (p value < 0.05/619).
  2. GO gene ontology.
Back to article page